The primary cause of incapacity is neuropsychiatric and neurological conditions including schizophrenia (SCZ), bipolar disorder (BIP), severe depressive disorder (MD), and Alzheimer's disease (Promotion). But for a really long time, a lack of understanding of their pathogenesis has hampered the development of effective and widely accepted neuropsychiatric therapies. However, given that these issues often have a high heritability, it is important for us to have a genuine understanding of the genetic causes of these diseases. Large-scale association studies (GWAS) have made significant progress in identifying disease-related variants. For instance, the Mental Genomics Consortium has identified numerous loci associated with SCZ and numerous other loci.
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