Journal of Clinical Case Reports

Erythema Multiforme in a Patient with Reactive Arthritis: Usefulness of Lymphocyte Stimulation Test for Detection of Sulfasalazine Hypersensitivity in a Case Report

Abstract

Rauno J Harvima* and Ilkka T Harvima

Skin eruption from sulfasalazine (salazosulfapyridine, Salazopyrin-^®) was indicated by lymphocyte stimulation test using various concentrations of the metabolites, sulfapyridine and 5-aminosalisylic acid. Only sulfapyridine produced a clear positive stimulation index. Later after about one year, the oral challenge resulted in negative results. The explanation of the developed tolerance for sulfasalazine remains unknown.

The results show that Lymphocyte Stimulation Test (LST) can be useful but may necessitate the use of a series of multiple dilutions in case of studying suspected allergens that possess antilymphocytic proliferative properties.