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Journal of Genetics and DNA Research

ISSN: 2684-6039

Open Access

Evaluating drug-chromatin interactions using novel methods for target engagement studies

Abstract

Marta Rucka

Regulation of gene expression is a dynamic process orchestrated and maintained by a large variety of chromatin-interacting proteins. Understanding these chromatin-protein complexes and their binding kinetics is crucial for development of the small-molecule drugs. Promega has developed NanoBRET technology, which allows for dynamic measurement of protein:protein interactions (PPIs) in living cells.

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