Depression Stress is a well-known risk factor for depression, and emerging research suggests that the relationship between stress and depression may be mediated by inflammation. Chronic stress can lead to increased production of pro-inflammatory cytokines, and in turn, chronic inflammation can sensitize the stress response system, perpetuating a vicious cycle. This bidirectional relationship between stress, inflammation, and depression highlights the complex interplay between these factors. The growing understanding of the role of inflammation in depression has significant implications for clinical interventions. Here are some potential strategies that target inflammation for the management of depression.
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