Vasculitis encompasses a group of autoimmune disorders characterized by inflammation and damage to blood vessels. Despite significant advancements in our understanding of the disease, the exact mechanisms underlying its development and progression remain unclear. Recent research has shed light on the potential involvement of the human microbiota in the pathogenesis of vasculitis. The microbiota refers to the diverse community of microorganisms residing in and on the human body. This article aims to explore the role of microbiota in vasculitis and its implications for disease pathogenesis and therapeutics. The human microbiota consists of trillions of microorganisms, including bacteria, viruses, fungi, and other microbes, primarily residing in the gut. It plays a crucial role in maintaining immune homeostasis and modulating inflammatory responses. Dysbiosis, an imbalance in microbiota composition, has been associated with various autoimmune diseases. Studies have shown alterations in the gut microbiota of vasculitis patients, suggesting its potential involvement in disease development. Influence on Disease Pathogenesis. Emerging evidence suggests that microbiota dysbiosis can influence vasculitis pathogenesis through multiple mechanisms.
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Journal of Vasculitis received 83 citations as per Google Scholar report
