Psoriasis vulgaris is a chronic inflammatory skin disorder characterized by dysregulated immune responses and abnormal keratinocyte proliferation. Emerging evidence suggests a potential link between vitamin K deficiency and the pathogenesis of psoriasis, highlighting the role of vitamin K in modulating inflammation, oxidative stress and tissue calcification. This pilot investigation aims to explore the prevalence of vitamin K deficiency in patients with psoriasis vulgaris and evaluate its association with disease severity and clinical outcomes. Serum levels of vitamin K and markers of inflammation, oxidative stress and vascular calcification will be measured in a cohort of patients with psoriasis vulgaris compared to healthy controls. Additionally, correlations between vitamin K status and disease activity, severity scores and treatment response will be analyzed. The findings from this pilot investigation may provide insights into the potential role of vitamin K in the pathophysiology of psoriasis vulgaris and inform future research directions and therapeutic strategies targeting vitamin K metabolism in the management of psoriasis.
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