Nuclear Medicine & Radiation Therapy

FDG-PET,a Complementary Modality to Computed Tomography in Radiotherapy Target Volume Delineation for Head and Neck Cancer

Abstract

Voichita Bar-Ad, Wenyin Shi, Madalina Tuluc, Nitin Ohri, David Cognetti, Joseph Curry and Charles Intenso

Objectives: The objective of the current review was to use published data to assess the role of [18F] fluorodeoxyglucose-positron emission tomography (FDG-PET) as a complementary modality to computedtomography (CT) in radiotherapy target volume delineation for head and neck cancer (HNC).

Methods: Studies were identified by searching PubMed electronic databases. Both prospective and retrospective studies were included. Information regarding the role of FDG-PET for radiotherapy target volume delineation for HNC was analyzed.

Results: FDG-PET is a promising tool for improving radiotherapy target volume delineation by defining a metabolically active biological target volume (BTV). The use of novel PET tracers representing properties such as hypoxia, protein synthesis and proliferation remain to be better characterized.

Conclusions: The role of FDG-PET for radiotherapy target volume delineation for patients with HNC is expanding and should be further evaluated in clinical trials.