Sayaka Ono, Yuko Nara, Toshihiko Sato and Shin-ichi Muramatsu
A 56-year-old woman complained of a three-month history of progressive clumsiness in her left hand. She reported fine hand movements to have become slow and uncoordinated, thus leading to moderate difficulty in dressing and working as a beautician. A neurological examination revealed rigidity in her left limb. No obvious tremors were noted. She was treated with L-dopa (300 mg/day), which provided substantial symptomatic benefits. MRI showed the putamen to have a normal morphology and size, and no areas of any altered signals were observed in the brain parenchyma (Figure 1A). Positron emission tomography (PET) with an aromatic L-amino acid decarboxylase (AADC) tracer, 6-[18F] fluoro-L-m-tyrosine (FMT) showed a reduced uptake in the posterior part of the right putamen.
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