The advent of Generation Z (Gen Z), comprising individuals born between the mid-1990s and early 2010s, has brought new challenges to the field of HIV care. This article explores strategies aimed at optimizing the care and support provided to the next generation of adolescents living with HIV within the Gen Z cohort. We examine the unique psychosocial, technological and healthcare-related factors influencing this generation's experience with HIV, including treatment adherence, disclosure, stigma and mental health. By synthesizing current research and insights from clinical practice, we propose innovative strategies that harness technology, community engagement and culturally sensitive interventions to enhance the care continuum for adolescents living with HIV in the Gen Z era. These strategies hold the potential to improve health outcomes, promote holistic well-being and reduce the long-term impact of HIV on this vulnerable population.
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