Background: Gout is a painful type of arthritis that occurs due to an increase in serum uric acid levels i.e. Hyperuricemia. Hyperuricemia is a worldwide health problem that is often dealt with Homeopathy. The objective of this review will be to assess the role of homeopathic medicines in the management of Hyperuricemia and primary Gout.
Methods/Design: To conduct syatematic review, authors will 3.6 search Medline, EMBASE, CENTRAL, AMED, CAM-Quest, CORE-Hom, ChiroACCESS (MANTIS interface), LILACS (Biblioteca virtual em salud interface), Google Scholar studies from January 2001 up to January 2022. The review will include all types of Randomised Controlled Trials (RCTs), Observational studies, well-presented case reports published in peerreviewed journals, in vitro studies and animal experimentation. Studies with participants of all ages and both sexes will be included. Cases with either acute gouty attack, those in inter critical period, or chronic gout will also be included. Studies related exclusively to allopathic and other CAMs (Ayurveda, Unani, Siddha, Yoga and Naturopathy) will be excluded from this review. The methodology will include Jadad scoring for clinical trials, the internal validity of RCTs by the Cochrane collaboration tool and the internal validity of observational studies and case reports by the Joanna Briggs Institute (JBI) criteria and JBI appraisal checklist, respectively.
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