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Journal of Diabetic Complications & Medicine

ISSN: 2475-3211

Open Access

Insulin Resistance Mechanisms, Implications and Therapeutic Targets

Abstract

Michael Seong*

Insulin Resistance (IR) is a condition characterized by a reduced response of target tissues to insulin, leading to impaired glucose homeostasis and increased risk of metabolic disorders, including type 2 diabetes mellitus (T2DM), cardiovascular diseases, and Non-Alcoholic Fatty Liver Disease (NAFLD). This review elucidates the multifaceted mechanisms underlying insulin resistance, discusses its clinical implications, and explores current and emerging therapeutic targets. Insulin resistance is a key pathological feature of several metabolic disorders, particularly T2DM. The condition is defined by the body's diminished ability to respond to insulin, which plays a critical role in glucose uptake and metabolism. Understanding the mechanisms of insulin resistance is vital for developing effective treatments and prevention strategies [1].

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