Chemical Sciences Journal

Isolation, In Silico Design and Anti-Inflammatory Activity of Spirosolenol from the Roots of Solanum anguvi

Abstract

B Mathew, GE Mathew, S George, M Shamnas, VBA Raj

The aim of our research was the isolation of the steroidal alkaloid glycosides such as anguivine and isoanguivine from the dried roots of S. anguvi and evaluation of their anti-inflammatory activity by HRBC and carrageenan induced paw edema method. The PASS programme predicts the anti-inflammatory activity of the aglycon part of spirosolenol, on the basis of a similarity structure based drug design. Molecular docking studies with human phospholipase A2 enzyme were carried outby utilizing Argus lab 4.0.1.version. The in silico study and pharmacological activity were correlated with good agreement.