The expression of core histone tiny chemical assembly instructions inside of living things is cell cycle controlled. Large amounts of histones are needed to restore copyd chromatin during S phase when DNA answer/copy happens. Over-expression and excess collection over time of histones outside S phase are poisonous to cells and therefore cells need to restrict histone expression to S phase. Misregulation of histone tiny chemical assembly instruction inside of living things expression leads to defects in cell cycle development or increase over time of events or things, total set of tiny chemical assembly instructions of a living thing firm and steady nature/lasting nature, DNA damage response and written version of spoken words al regulation. Here, we discussed the factors involved in histone tiny chemical assembly instruction inside of living things regulation as well as the hidden under machine. Understanding the histone regulation machine/method/way will shed lights on explaining the side effects of certain cancer chemotherapeutic drugs and developing possible biomarkers for tumor cells. The whole total set of tiny chemical assembly instructions of a living thing sequences of many living things have suggested that all the tiny chemical assembly instructions inside of living things present in any oraganism are not active at the same time. It seems that there are inbuilt internal machines that usually in a common and regular way guide that which tiny chemical assembly instruction inside of living things will be active and which active tiny chemical assembly instruction inside of living things will be shut down. The machines/methods/ways involved in the expression and regulation of tiny chemical assembly instructions inside of living things are controlled by many factors such as methylation, acetylation, phosphorylation, role of silencers, different upstream or RNA polymerase binding copying DNA segments into RNA factors and natural interfering RNA.
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