Medicinal Chemistry

Mathematical Formulas for Some Cross-Β Structures of Human Aβ Protein

Abstract

Jiapu Zhang

For amyloid fibril cross-β structures of Aβ human protein, we find theoretical calculations are agreeing with laboratory X-ray crystallography experiments. This mini article summarized mathematical formulas of amyloid fibril cross-β structures of segments of human Aβ protein. These formulas are accurate and correct some data in the Protein Data Bank (PDB). However, more mathematical formulas for core Chains AB (PDB IDs: 3OW9, 3PZZ, 2OKZ), or ABGH (PDB IDs: 3OVJ, 2Y3J, 2Y3K, 2Y3L) (or ABCD (PDB ID: 2ONA)) are still needed to present and optimize.