Journal of Bioanalysis & Biomedicine

Melatonin: the Weapon Against Oxidative Stress and Nitrosative Stress in Neurovascular Diseases

Abstract

Muhammad Masood Ahmed, Ji-Yun Huang, Rong-rong Tao and Feng Han

The multiple lines of evidence demonstrate that melatonin exerts powerful antioxidant actions by preventing and
scavenging free radicals in a direct and indirect manner. Importantly, melatonin reduced post-ischemic oxidative/
nitrosative damage to the afflicted neurovascular units and improved the preservation of blood-brain barrier
permeability in various brain diseases. The information compiled here will serve as a comprehensive reference
for the neurovascular protective actions of melatonin to date, and will hopefully help to design further experimental research and expand melatonin as neurovascular protective agent in neurovascular diseases.