Chemical Sciences Journal

Microwave-Assisted One-Pot Synthesis of Novel 1-Phenylethylhexahydroquinazolin-5(6H)-ones and Bis-1-Phenylethylhexahydroquinazolin-5(6H)-ones

Abstract

M Saha, E Karim, JN Vishwakarma

A facile microwave-assisted one-pot synthesis of novel 1-phenylethylhexahydro quinazolin-5 (6H)-ones 3a–j and bis-1-phenylethylhexahydro quinazolin-5 (6H)-ones 4a–f and 5a–d has been devised by the cyclocondensation of cyclic enaminones 2a–b with primary amines/diamines and formaldehyde. The structures of the products have been established with the help of spectral and analytical data.