Biosensors & Bioelectronics

Model-Based Quantification of Blood Flow Rate and Oxygen Consumption Rate of Biological Tissues Using Image-Guided Near Infrared Light Spectroscopy

Abstract

Zhen Yuan

Image-guided near infrared spectroscopy has been implemented to deduce the map of oxygen consumption rate and blood flow rate of biological tissues using a model-based method combined the noninvasive diffuse light measurement techniques. The developed method relies on optical imaging to recover the concentrations of oxygen and de-oxygen hemoglobin concentration of tissues, and the ordinary differential equations to recover the vascular parameters including oxygen consumption rate and blood flow rate. In particular, the mathematical model has been validated by both simulation and experimental tests.