Molecular Biomarkers & Diagnosis

Modeling Tumor Initiation as Ricci Flow

Abstract

Robert Skopec

Small variations in magnetic fields can be environmental stresses. For example cell phones, which give off very weak magnetic fields. It is a question, whether these magnetic fields cause brain tumors in cell-phone users. We can model cancer as invasion from social, through psychological to deepest molecular level by Ricci flow. Mechanism of integrated stress response starts with rapid hormone induced changes in receptor conformation which lead to slower modulations of gene transcription. Inhibition of programmed cell death is a major aspect of tumorigenesis (by oncogenic transcription factors NF-kB, STAT3) through upregulation of survival genes. The afferent input from the limbic network conveys purely psychological stress reactions to the HPA axis. Even dominant oncogenes such as v- Src or K-Ras are unable to induce cancer in adult animals without injury. A strong tumor-associated inflammatory response is initiated by the dynamics of Ricci flow collapsing into an injury point that becomes a rounder cellular dysfunction. Tufts biologists show bioelectrical signals control tumors arising from cancer-causing genes; fatty acid involved in process. The have proved, that cancer, bioelectrical signals and the microbiome are connected.