The goal of this study was to evaluate both historical and contemporary literature reviews as well as case studies in order to inform how histological stains have changed in the modern period. The results of the literature research showed that histopathology and histotechnology in terms of stains utilised have improved. There has been an increasing demand for staining techniques that are accurate, effective, and simple. Many staining techniques have been supplanted by new immunostaining, molecular, non-culture, and other advanced staining techniques, but many others are still in use today. Because the necessary chemicals have been shown by science to be harmful, some staining techniques have been abandoned. The case studies showed that current histology uses a combination of many stain procedures to increase the staining process' efficacy. In order to increase their efficiency, better histology stains have been changed and mixed with other stains.
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