Medicinal Chemistry

Molecular Heterogeneity of Type 2 Diabetes Mellitus in Mexican Population and its Impact of the Public Health on Policies in Primary Care

Abstract

Luis Javier Flores- Alvarado, Sergio Alberto Ramirez- Garcia, Pedro Duran Ferman, Nory O Davalos- Rodriguez, Claudia Chavéz- Lopez, Jareth Marco Cruz- Bastida, Carlos Alberto García- Aguila and Carlos Enrique Cabrera Pivaral

Type 2 diabetes mellitus is a complex disease and a global health problem; hence the first level of health care should handle the approaches of medical genetics to reduce its incidence. In this manuscript we present perspectives of the study of genomic medicine carried out in Mexican population, which show a molecular heterogeneity according to the studied population. Genes currently associated to diabetes are fifty, including ABCA1, APOE, BGLAP, LRP2, CYP19A1, hIAPP, SCARB1, TCF7L2, TNFA. Up to date there are no variants related to diabetes mellitus in the HNF1β, INS, and NEUROD1 among other genes. In relation to chronic complications of DM2, the genes ACE, ADRB3, APOE, CUBN, hANP, LRP2 and HPSE are analyzed.