Journal of Genetics and DNA Research

Mutant p53 leads to enrichment of cancer stem cells that display ESC expression signature

Abstract

Gabriela Koifman

Mutation in the p53 gene is a frequent alteration in human cancers which mostly leads to the acquiring of new oncogenic functions that promote tumorigenesis. In this study, we observed that bone marrow derived from mutant p53 mice exhibit higher ability to form tumors compared to WT-MSCs.