Journal of Clinical Case Reports

Neuroendocrine Carcinoma in 2 Cases of Rare Primary Small Cell Carcinoma of the Breast and its Literature Review

Abstract

Bingxue Yan, Shifen Huang, Yunxia Xia, Fang He and Xiaoling Ling*

Primary Small Cell Neuroendocrine Carcinoma of the Breast (SCNCB) is rare and invasive, which lacks a standard therapy. Small cell carcinoma is a subtype of Small Cell Neuroendocrine Carcinoma (SCNC) and common in lung. It is difficult to distinguish small cell carcinoma in breast from which in the lung. Therefore, a whole-body scan is necessary to rule out metastasis from the Extra pulmonary Small Cell Carcinoma (EPSCC). This article reports two patients with SCNCB and reviews relevant literature to comprehensively discuss the diagnosis and management of this disease in these two cases.