Korliana Strna
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder
that leads to severe cognitive decline, memory impairment, and changes in
behavior and personality. It is the most common cause of dementia, affecting
millions of individuals worldwide, with an increasing prevalence as the global
population ages. The pathophysiology of Alzheimer's disease is multifactorial,
involving the accumulation of amyloid plaques, tau tangles, inflammation, and
synaptic dysfunction. One of the most critical factors in the cognitive decline
observed in AD is the dysfunction of neurotransmitter systems, particularly
the cholinergic system, which involves Acetylcholine (ACh) as its primary
neurotransmitter.
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