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Clinical Depression

ISSN: 2572-0791

Open Access

Neurotransmitter Imbalance and its Role in Parkinson?s disease: Mechanisms and Therapeutic Approaches

Abstract

Gawlin Ruthwik

Parkinson’s Disease (PD) is a chronic and progressive neurodegenerative
disorder that primarily affects movement control. It is the second most common
neurodegenerative disorder after Alzheimer's disease, with a significant
impact on the quality of life of affected individuals. PD is characterized by the
degeneration of dopaminergic neurons in the substantia nigra, a region of the
brain that plays a crucial role in motor control. As dopamine-producing neurons
are lost, there is a corresponding imbalance in the neurotransmitter systems of
the brain, leading to a wide range of motor and non-motor symptoms, including
tremors, bradykinesia, rigidity, postural instability, and cognitive decline.

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