Journal of Genetics and DNA Research

Nonclinical characterization of the novel IL-1 heterodimeric fusion protein RPH-104

Abstract

Anastasia Dmitrieva

Interleukin-1 (IL-1), a central mediator of innate immunity and inflammation, plays a pivotal role in a broad spectrum of inflammatory diseases. RPH-104 is a novel IL-1 antagonist: a heterodimer comprised of human extracellular portions of IL-1RI and IL-1 receptor accessory protein, each linked to a mutant Fc portion of human IgG1. Aim: The aim of the studies is preclinical characterization of RPH-104.