Molecular Biomarkers & Diagnosis

Non-Coding RNAs as Emerging Biomarkers for Cardiometabolic Diseases: A New Frontier in Diagnostics

Abstract

Huanhuan Lv*

Non-coding RNAs (ncRNAs), which are RNA molecules that do not translate into proteins, have emerged as critical regulators in various biological processes, including gene expression, cellular development, and metabolism. Recent advancements have highlighted the significant role of ncRNAs in the pathophysiology of Cardiometabolic Diseases (CMD), including cardiovascular diseases, diabetes, and obesity. These diseases are a leading cause of morbidity and mortality globally, and their prevalence continues to rise with changing lifestyles and environmental factors. ncRNAs, particularly MicroRNAs (miRNAs), Long Non-Coding RNAs (lncRNAs), and Circular RNAs (circRNAs), have been shown to influence crucial biological pathways involved in inflammation, lipid metabolism, glucose homeostasis, and vascular function. Their ability to regulate gene expression and signaling pathways makes them potential biomarkers for early diagnosis, prognosis, and therapeutic intervention in CMD.