Chemical Sciences Journal

Novel Benzodiazepine Derivatives: Synthesis, Characterization, and Anticonvulsant Activity

Abstract

Ahmed Elessawy*, Eman A. El-Bastawissy and A.A. El-Barbary

New benzodiazepine derivatives namely; N-(4-methoxyphenyl)-4-methyl-3H-benzo[b][1,4]diazepin-2-amine (1) (13(Z)-4-amino-5-(2-((4-methoxyphenyl)amino)-4-methyl-3H-benzo[b][1,4]diazepin-3-ylidene)-6-methyl-4,5-dihydro-1,2,4-triazine-3(2H)-thione (2) and N-(4,6-dichloro-1,3,5-triazin-2-yl)-N-(4-methoxyphenyl)-4-methyl-3H-benzo[b][1,4]diazepin-2-amine (3) have been prepared and characterized by spectroscopic methods (FT-IR, ¹H-NMR, UV-visible and EI-mass). Finally, the study of the effect on the anticonvulsant activity of clonazepam derivatives exhibits that derivatives caused a significant decrease in the number of mice with convulsions compared to untreated control groups.