Medicinal Chemistry

Novel Upconversion Fluorescent Probe for Schistosoma japonicum Cercariae Imaging

Abstract

Yulan Fan, Yunzhi Xie, Linxiu Chen, Wei Liu, Xun Li, Yibao Li and Xiaolin Fan

Schistosomiasis has influence on people’s security and daily life significantly, while cercarial stage of the schistosome life-cycle is the only infectious period. To detect cercarial efficiently, we synthesized rare-earth upconversion nanophosphors UCs-Ni loaded with niclosamide. The fluorescenceof UCs-Ni was demonstrated by the fluorescence emission spectra. The cell imaging test illustrated that UCs-Ni was biocompatible, cell-permeable and suitable for cercariae imaging. When it has been utilized for cercariae imaging, we found that the UCs-Ni could penetrate into cercariae.