As the global population ages, maintaining musculoskeletal health becomes increasingly important to preserve mobility, independence and overall quality of life among older adults. While individual macronutrients and micronutrients have been extensively studied for their roles in musculoskeletal health, emerging evidence suggests that nutrient synergy, the combined impact of multiple nutrients, may exert greater benefits than isolated nutrient supplementation. This review explores the concept of nutrient synergy in the context of musculoskeletal health in gerontology, focusing on the interplay between macronutrients (protein, carbohydrates and fats) and micronutrients (vitamins and minerals). Key topics covered include the synergistic effects of nutrients on bone density, muscle mass, strength and physical function in aging populations. Additionally, the role of nutrient interactions, bioavailability and dietary patterns in optimizing musculoskeletal health outcomes will be discussed. By synthesizing current research findings, this review aims to provide insights into the potential benefits of nutrient synergy for promoting musculoskeletal health in older adults and inform future research and clinical practice in gerontology.
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