With the continuous development of economy and the acceleration of social transformation, the contradiction between regional economic development and discipline construction in universities is becoming more and more prominent. It is urgent to explore the coupling and coordination relationship between the two to achieve higher-quality development. At the same time, Hubei Province is a big education province in China and it is also one of the important areas of the rise strategy of central China. Taking Hubei Province as an example to study has certain representativeness and demonstration significance. Therefore, this paper builds the economic development and subject construction of colleges and universities in two comprehensive evaluation index system, selection of Hubei province in 2010-2019 and the 13 regional administrative region economic development and subject construction of colleges and universities in two system index data, using poor method and principal component analysis to data standardization and index weight calculation, two comprehensive evaluation index system, The results show that both of them increase steadily, the comprehensive evaluation index of economic development subsystem increases from 0.0962 to 0.9519, and the comprehensive evaluation index of university discipline construction subsystem increases from 0.1303 to 0.8438. Then the coupling coordination degree model was adopted, and the ArcGIS software was used to measure the coupling coordination relationship between the two systems and analyse the spatial pattern evolution. Finally, the Granger causality test method was used to test the coupling relationship between the two systems. The results show that the coupling coordination degree of the two systems in Hubei Province has changed from mild misalignment to high quality coordination, and has been developing continuously. The spatial distribution of administrative regions at different levels is not consistent, there is false coupling, and most of them are low level coordinated development. Economic development is insufficient in supporting the discipline construction in colleges and universities. Suggestions are given: the government should plan the two systems synchronously to make them develop harmoniously; Colleges and universities should actively respond to the policy call of "Double First-class" and improve the discipline construction system; Normal financial support system for discipline construction should be established between government and university, so as to give full play to the "Economic Education Power" of regional economy during the COVID-19 pandemic.
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