Medicinal Chemistry

One-Pot Synthesis of Novel Substituted Phenyl-1,5-dihydro-2Hbenzo[ 4,5]thiazolo[3,2-a]pyrimido[4,5-d]pyrimidine Derivatives as Potent Antimicrobial Agents

Abstract

Talavara Venkatesh, Yadav D Bodke, Nagaraj K and Ravi Kumar S

In this paper, we have reported the synthesis of novel substituted phenyl-1,5-dihydro-2H-benzo[4,5] thiazolo[3,2-a]pyrimido[4,5-d]pyrimidine derivatives (4a-m). The title compounds were synthesized by the reaction of substituted 2-aminobenzothiazole, barbituric/thiobarbituric acid and substituted benzaldehydes using 2-3 drops of HCl in ethanol. The synthesized compounds were evaluated for their antimicrobial efficiency against various microbial strains at different concentrations. Among the tested compounds, the compounds 4k and 4j were found to be more active against all the tested pathogens. Additionally, selected compounds were screened for in silico molecular docking studies.