The treatment of brain tumors, particularly glioblastomas, remains a formidable challenge due to the development of resistance to conventional therapies such as surgery, radiotherapy, and chemotherapy. This review examines the underlying mechanisms of therapeutic resistance in brain tumors and explores innovative strategies to overcome these obstacles. We highlight advances in molecular biology, immunotherapy, precision medicine, and combination therapies that offer new hope for enhancing treatment efficacy. By analyzing recent research and clinical trials, this review provides insights into current approaches to counteract resistance and discusses future directions for research and clinical practice.
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