The development of an HIV vaccine represents one of the greatest challenges in modern medicine. While significant progress has been made in understanding the virus and its mechanisms, the road to a fully effective vaccine remains fraught with immunological hurdles that researchers are still striving to overcome. Unlike many other infectious diseases, HIV is uniquely challenging due to its complex behavior, rapid mutation, and ability to evade the immune system. These factors have made it difficult to develop a vaccine that can provide lasting protection against the virus. One of the most critical challenges in developing an HIV vaccine is the virus’s ability to rapidly mutate. HIV is a retrovirus, which means that after entering the body, it converts its RNA into DNA and integrates it into the host’s genome. This process is highly error-prone, leading to a constant reshuffling of the virus’s genetic code. As a result, HIV can quickly generate numerous variants, making it exceedingly difficult to create a vaccine that can target all potential strains.
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Journal of AIDS & Clinical Research received 5264 citations as per Google Scholar report
