One of the most fatal forms of cancer is pancreatic ductal adenocarcinoma, with a median survival time of less than six months. PDAC patients have few therapeutic options, and surgery is still the most effective treatment, so early diagnosis is critical. The desmoplastic reaction of its stroma microenvironment, which actively interacts with cancer cells to orchestrate crucial aspects of tumorigenesis, metastasis, and chemoresistance, is one characteristic of PDAC. To decipher PDAC biology and develop intervention strategies, it is essential to conduct global research on cancer-stroma crosstalk. The rapid advancement of proteomics technologies over the past ten years has made it possible to profile proteins, post-translational modifications, and their protein complexes with an unprecedented level of dimensionality and sensitivity. Here, beginning with our ongoing comprehension of PDAC qualities, including forerunner sores, movement models, growth microenvironment, and remedial headways, we depict how proteomics adds to the utilitarian and clinical investigation of PDAC, giving experiences into PDAC carcinogenesis, movement, and chemoresistance. We sum up late accomplishments empowered by proteomics to efficiently examine PTMs-intervened intracellular motioning in PDAC, disease stroma collaborations, and potential helpful targets uncovered by these practical examinations.
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Research and Reports in Medical Sciences received 13 citations as per Google Scholar report
