Journal of Clinical Case Reports

Pediatric Osteo-Lymphoma: A Literature Review and Case Study

Abstract

Wang F, Altine B, Cheng C, Peng X, Lan X, Zhang Y and Shao J

Background: Osteo-Lymphoma is a bone tumor that could be found in children. The world health organization (WHO) has defined Osteo-Lymphoma as lymphoma that affect only bones without the involvement of soft tissue organs. Osteo-Lymphoma is very rarely found lymphoma in pediatric patients and accounts for about 3% to 7% of bone malignancies and 4% to 5% of extranodal lymphomas. The aim of this study was to review bone lymphoma of pediatric patient, and to report Osteo-Lymphoma case diagnosed in imaging department of our hospital including Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT). Case presentation: A 6-year-10-month old Chinese male (weight: 25 Kg, height: 120 cm) was admitted to our hospital for 2 months’ bilateral lower extremities pain. He had more aggravated pain in both elbows lately associated with 15 days’ headache. This patient underwent for different investigations including imaging. The imaging investigations have found multiple Osteo-Lymphoma and soft tissue tumors on forehead and right parietal
bone. In addition, differential diagnosis cases from our data base were also presented and compared. The patient underwent surgery for the removal of forehead and right parietal tumors. The samples of the resected tumors were sent for immunohistochemistry analysis that confirmed the diagnosis as B cells lymphoma. Therefore, the patient was treated on the hospital standard chemotherapy regimen that is usually used in lymphoma. Conclusion: The patient follow-up whole body SPECT/CT and other clinical tests have revealed treatment good
outcomes.