Mucormycosis is a rare, opportunistic, aggressive infection caused by fungi which frequently infects the brain, sinuses, or lungs, rarely skin, GIT. Primary cutaneous infection in humans is limited to patients with severe immunocompromised status. This is a case of middle aged immunocompetent patient with primary cutaneous mucormycosis infection of the anterior abdominal wall with involvement of bilateral inguinal lymph nodes causing deep vein thrombosis and eventual gangrene of lower limb. The potential life threatening condition was averted with timely intervention, although his limb could not be salvaged. Diagnosis and timely management of mucormycosis still remains a challenge. The key to the diagnosis lies is the identification of the important risk factors and hallmark symptoms and a quick histopathological diagnosis. Awareness, early recognition, extensive and aggressive diagnostic procedure, prompt surgical intervention and initiation of an appropriate antifungal treatment are crucial in the management of this uncommon but potentially limb and life threatening infection.
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