Medicinal Chemistry

Pl3K/Akt/NF-κB Signalling Pathway on NSCLC Invasion.

Abstract

Hakan Kucuksayan H, Sakir Akgun S and Akca H

Invasion is a crucial step of metastasis process that has a complex mechanism and inducible various cellular signalling pathway (SMADs, JAK/STATs, PI3K/Akt and MAP kinases). In among these pathways, Pl3K (phosphatidylinositol-3-OH kinase)/Akt/NF-ĸB (nuclear factor-ĸB) signalling pathway is an important on cellular invasion and its constitutively active in various human cancer, including non-small cell lung cancer (NSCLC). PI3K/Akt/NF-ĸB pathway has been associated with multiple cellular function; migration, apoptosis, proliferation, survival, and also differentiation. Thus, this signalling pathway plays a major role not only in tumorigenesis but also in a potential target for cancer treatment. It has been investigated that there are lots of observation about Pl3K/Akt signalling pathway on many cancers, especially NSCLC. But, it is not enough to completely understanding the molecular mechanism of NSCLC invasion. In this review, we will briefly discuss the molecular mechanism of PI3K/Akt/NF-ĸB signalling pathway in NSCLC invasion.