Louis Erin
Plant-based vaccines have emerged as a promising alternative to traditional vaccine production methods, leveraging the advantages of plant expression systems for antigen design, diversity, and large-scale production. Unlike conventional vaccines produced in microbial, insect, or mammalian cell cultures, plant-based systems offer scalability, cost-effectiveness, and enhanced safety due to their inability to harbor human pathogens. The use of genetically modified plants for vaccine production has led to innovative approaches in antigen engineering, allowing for the development of highly immunogenic and stable vaccine candidates. Antigen design is a crucial aspect of plant-based vaccine development, as the effectiveness of the vaccine depends on the ability of the expressed antigen to elicit a strong and protective immune response. Various strategies have been employed to optimize antigen expression in plants, including codon optimization, fusion to carrier proteins, and targeting to specific cellular compartments such as the endoplasmic reticulum or chloroplasts. The use of viral or bacterial signal peptides has been shown to enhance protein folding and stability, improving antigen yield and bioavailability.
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Journal of Genetics and DNA Research received 3 citations as per Google Scholar report
