Alok Sharma, Pooja Kulkarni, Hemangi Sane, Nandini Gokulchandran, Prerna Badhe, Mamta Lohia and Priti Mishra
Cerebral palsy is defined as motor impairment that limits activity, and is caused by non-progressive disruption during cerebral development in fetus or infant. The standard treatment is focused on rehabilitation and symptomatic management, which does not address the underlying brain damage. Recently cellular therapy has been seen as promising strategy to improve function of damaged areas of brain. Many mechanisms of action are postulated including cytokine release, angiogenesis, activation of satellite cells, decrease inflammation decrease neuronal apoptosis; and neuronal regeneration. We present a case of a two year old girl with spastic cerebral palsy, who was administered autologous bone marrow derived mononuclear cells intrathecally. Six months after the therapy she showed significant functional improvements along with correlating dramatic changes in Positron Emission Tomography-Computed Tomography scan. These changes provide objective evidence of functional restoration of affected areas of brain by cellular therapy.
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