Medicinal Chemistry

Potential for Biomedical Applications of Galactomannans and Xyloglucans from Seeds: An Overview

Abstract

Guilhermina Rodrigues Noleto and Carmen Lúcia Oliveira Petkowicz

Galactomannans and xyloglucans can be isolated from seeds with relatively high purity and yield; they are water soluble, non-toxic, and biocompatible. These polymers have broad spectra of potential use in medicine, from drug delivery systems to biological response modifiers. The biological activity of polysaccharides is intrinsically linked to their structural aspects. In general the chemical modification of galactomannans and xyloglucans, e.g., sulfation and complexation with oxovanadium, potentiate effects such as cytotoxicity against tumor cells, leishmanicidal activity, and activation of macrophages to release proinflammatory mediators. The wide range of seeds and structural variety favor the isolation of galactomannans and xyloglucans. This allows derivatives to be obtained with targeted properties and activity enabling their use in new applications in the biomedical area.