The COVID-19 pandemic has presented a unique challenge to global public health, with a significant proportion of individuals experiencing prolonged symptoms even after the acute phase of the illness. This extended COVID-19 syndrome, often referred to as "long COVID," encompasses a range of persistent symptoms affecting multiple organ systems. Understanding the factors contributing to susceptibility to this condition is crucial for effective management and treatment. This article explores the role of predictive factors and polymorphisms of the ACE-2 gene in determining susceptibility to extended COVID-19 syndrome. The COVID-19 pandemic has highlighted the wide spectrum of disease severity and the emergence of extended COVID-19 syndrome, characterized by persistent symptoms beyond the acute phase of infection. Understanding the host factors influencing susceptibility to prolonged illness is crucial for patient management and risk stratification. This review synthesizes current literature on predictive factors and polymorphisms of the angiotensin-converting enzyme 2 genes in the susceptibility to extended COVID-19 syndrome. Relevant articles published up to January 2024 were included, focusing on studies investigating genetic variants of ACE-2, their association with disease outcomes and predictive factors for prolonged illness.
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