Cerebrospinal Fluid (CSF) serves as a crucial source of biomarkers for various neurological disorders due to its proximity to the central nervous system. Recent advancements in proteomic techniques have enabled comprehensive profiling of the CSF proteome, shedding light on the molecular mechanisms underlying neurological conditions. Furthermore, the investigation of Extracellular Vesicles (EVs) within the CSF has emerged as a promising avenue, offering valuable insights into intercellular communication and disease pathogenesis. This article provides an overview of proteomic approaches applied to CSF and its EVs, highlighting their significance in the diagnosis, prognosis and therapeutic development for neurological disorders.
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