Metastatic tumors to oral cavity are rare and represent approximately 1% off all cases of oral malignat lesions even though metastatic disease may be present. The 53-year-old female presented in March of 2017 complaining with abdominal pain, weight loss and loose stool not more than 3 times per day. CT scan of the abdomen in July showed retroperitoneal mass expanding along the body of the pancreas. Colonoscopy and gastroscopy with biopsy of mucosa of the stomach showed normal result. The tumor marker Ca 19-9 in July 2018 was 110.3 and in August 2018 350.6. The patient was referred in September of 2018 to the maxillofacial surgery Clinic for examination of the lesion in the oral cavity. She presented with a pain, swelling and occasional bleeding around the lower right second mollar. Immunohistochemical the tumor cells were positive for Cytokeratin (CK) 19, Cytokeratin (CK) 7, and homebox protein (CDX-2) which is highly sensitive markers of pancreatobiliar cancer. Therefore, the patient was diagnosed with pancreatic carcinoma. This report describes a rare metastasis of malignant pancreatic tumor in lower right gingiva and highlights the importance how immunohistochemical examination ped to identify both the origin and the nature of gingival neoplasm.
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