Due to their ability to modify signalling pathways by binding to phospho-writers, erasers, and readers like proteins with SH2 and PTB domains, phosphotyrosine-containing compounds are the focus of considerable research. In order to research protein phosphorylation and dephosphorylation, phosphotyrosine derivatives are helpful chemical tools. As a result, they are appealing starting points for the creation of binding ligands, chemical probes to study biology, and inhibitor and degrader drug design. Physiologically stable phosphonate-based phosphotyrosine analogues are useful in a wide range of applications to overcome the enzymatic lability of the phosphate group.
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