Medicinal Chemistry

Recent Development of Benzotriazole-based Medicinal Drugs

Abstract

Yu Ren, Ling Zhang, Cheng-He Zhou and Rong-Xia Geng

The extensively clinical use of triazole-based medicinal drugs has been promoting increasing effort to develop new structural triazole derivatives. Benzotriazoles as fused aromatic nitrogen heterocycles of benzene ring with triazole exhibit wide potentialities in medicinal chemistry since some anticancer benzotriazole compounds like vorozole and 4,5,6,7-tetrabromo-1H-benzotriazole (TBB) were used in clinical therapy. The benzotriazole related investigations are becoming increasingly active. On the basis of authors’ researches and other literature in recent five years, this work for the first time gave a comprehensive review on the latest and outstanding developments of benzotriazole compounds in medicinal chemistry, including as anticancer, antifungal, antibacterial, antitubercular, antiviral, antioxidative, antiparasitic, antioxidative agents and so on. Hopefully, this contribution will be helpful to develop benzotriazole-based drugs with high bioactivity and low toxicity.