Journal of Immunobiology

Regulating DCs in Innate Immune Response and Infection by Cytoskeletal Proteins

Abstract

Wei Lin and Xin Wang

Dendritic cells (DCs) are important antigen-presenting cells of innate immune system. Their main function is to take up antigen and present it to T-cells to active adaptive immune response. The cytoskeletal proteins of the DCs not only maintain the morphology of DCs, but also are associated with the maturation and function of DCs. Additionally, rearrangement of cytoskeletal proteins is associated with viral infection in DCs. Regulating the specific cytoskeletal proteins of DCs would be a potential therapeutic strategy for preventing viral infection. Thus, the role of cytoskeletal proteins of DCs in immune response and viral infections were reviewed.