Nuclear Medicine & Radiation Therapy

Risk Evaluation of Secondary Cancer Induced by Breast Cancer Radiotherapy Treatment

Abstract

Ibrahim Duhaini, Fatima Hijazi, Eva Sabbah, Saad Ayoubi, Sadek Nehmeh, Ahmad Marouf, Mahmoud Korek

The Radiotherapy technologies are one of the most common treatments for cancer, they have been successfully used to damage cancer cells, with as little harm as possible to nearby healthy cells, however Secondary cancer risk following radiotherapy is an increasingly important topic in clinical oncology with impact on treatment decision making and on patient management. The paper aims to investigate and evaluate the current practice in radiotherapy through its different phases and to quantify the risk of secondary primary cancer following radiotherapy in breast cancer by dose calculation and risk estimation of second cancer; to make recommendations for a safer practice in radiotherapy department. The data collected from NBGUH and RHUH with dosimetry calculations on retrospective female patient’s files and verifies with dose measurements on RANDO Phantom.
The results showed 85% of compliance in radiotherapy safe practices, calculated Probability of Causation after breast radiotherapy for contralateral and Ipsilateral breast cancer 0.17%, and for lung is 32%, for spinal cord is 24%. While the PC in phantom measurements in Ipsilateral lung 43.22% and PC for contralateral lung 3.099%.