Journal of Cytology & Histology

Role of CD10 Immunoshistochemical Expression in Discriminating the Categories of Phylloides Tumor

Abstract

Muhammad Usman Tariq, Saroona Haroon and Naila Kayani

Background and objectives: Phylloides tumors are categorized as benign, borderline and malignant on the basis of histological features which are subjected to significant inter-observer variability. Our aim was to study the role of immunohistochemical expression of CD10 in discriminating benign, borderline and malignant categories of phylloides tumor.
Methods: The expression of CD10 was studied in 85 phylloides tumors (27 benign, 25 borderline, and 33 malignant) using immunohistochemistry to see whether the expression differed between these histologic categories. Chi-square test was applied to determine the significance of difference in CD10 expression among tumor categories. Significance was established at p<0.05.
Results: 5/27 (18.5%) benign, 16/25 (64%) borderline and 26/33 (78.8%) malignant cases expressed significant (2+ or 3+) staining. This expression of CD10 significantly varied among histological categories (p<0.001). Histological features such as stromal atypia, stromal cellularity, tumor margins, mitotic activity and tumor size correlated significantly with tumor categories as well as with CD10 expression.
Conclusion: From these highly significant results, we believe that there is a strong correlation between CD10 expression and tumor grade and it can be used as an adjunct diagnostic tool for categorizing Phylloides tumors along with other histological features.