Molecular Biomarkers & Diagnosis

Salivary Peptidomic Analysis -The Extension of Proteomics

Abstract

Jieni Zhang, Yan Li, Qingwei Ma, Jiuxiang Lin and Feng Chen

Nowadays, proteomic-related studies have developed rapidly and improvement has been made in the scientific and technological fields. Besides the proteome, the peptidome with low molecular weight has apparently attracted increasing attention in recent years too. The peptidome performs a large array of vital biological functions to contribute to homeostasis in the certain tissues. However, due to the interference by high-abundance proteins in complex biological body fluids such as saliva and serum, selective enrichment of peptides with low molecular weight is the first and most important step before analyzing the peptidome. This review mainly illustrates the general concept of the peptidome, specific methods of saliva collection, advanced peptidomic technologies and the recently developed peptidomic-related reports, as well as some limitations of the application in salivary peptidome. The future prospects of the peptidome are also involved.