SARS-COV 2 infection is usually associated with platelet count alterations. In most cases, platelet dysregulation manifests with mild to severe thrombocytopenia. We report the cases of two patients, blood related, who were hospitalized in our department due to SARS-COV2 infection accompanied by mild to severe thrombocytosis. Thrombocytosis is a rare manifestation in COVID-19 patients. Follow-up tests demonstrated a quick return of platelets within normal range, making the diagnosis of secondary thrombocytosis due to SARS-COV 2 infection the most likely diagnosis. Moreover, the blood relation between the two patients creates a suspicion that excessive platelet reaction could be due to genetic predisposition.
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